Saint Obi majored in theatre arts at the University of Jos. Saint Obi came into the acting scene in 1996, after doing a commercial for Peugeot on NTA. He has starred in over 60 movies.
In 2001, Saint Obi produced his first movie titled Take Me to Maama, where he starred as Jerry, alongside Ebi Sam, Rachel Oniga, Nse Abel and Enebeli Elebuwa.