It is the second time the club from southeastern city Aba have faced such a deficit in the elite African competition, and are hoping for a more successful outcome.
Enyimba suffered a 4-1 loss away to ASEC Mimosas of the Ivory Coast in a 2002 qualifier and a 3-1 home victory was insufficient to avoid elimination.
Here, AFP Sport puts the spotlight on five intriguing return matches as clubs seek overall victories, group places, and a minimum payout of $550,000 (450,000 euros).
Enyimba v Merrikh
Ghana-born Enyimba midfielder Farouk Mohammed has not given up hope of a spectacular second leg comeback that would require his team to score at least three times to have any chance of survival.
“The heavy loss we suffered in Sudan com