Holders Chelsea will take on 11-time winners Real Madrid for a place in the last four. Manchester City face Atletico Madrid, who dumped Manchester United out of the competition.
Villarreal have been drawn against Bayern Munich, while Liverpool play Benfica.
FULL FIXTURES:
Chelsea vs Real Madrid
Manchester City vs Atletico Madrid
Villarreal vs Bayern Munich
Benfica vs Liverpool
The UEFA Champions League is an annual club football competition organised by the Union of European Football Associations and contested by top-division European clubs, deciding the competition winners through a round robin group stage to qualify for a double-legged knockout format, and a single leg final.