This is coming five years after the UFC superstar lost to the American in a TKO defeat.
Fight Hype reports that the pair are in discussions over a second bout, with McGregor adding to the speculation with a cryptic post on social media.
McGregor has not fought in almost a year since suffering a horrific broken leg in his defeat to Dustin Poirier.
He shared a picture of his clash with Mayweather on Instagram on Thursday evening, June 23.
Captioning the picture “I accept”, he hinted at the pair facing off again.
Mayweather’s victory against The Notorious proved to be his last ever pro fight, taking his record to 50 wins and zero losses or draws.
It’s uncertain that the rematch between the duo would hold.